If you use some other Adblocker, such as AdBlock Plus or “AdBlock”, delete it before installing uBlock Origin. Nano Adblocker is legit fork though and I recommend it.
More information about installation on uBO’s Github: https://github.com/gorhill/uBlock
Keep in mind, that some browsers do not support these features, such as Safari.
For blocking annoyances etc. which aren’t blocked out of the box.
Stuff may more likely break if you enable these lists: